醛糖还原酶
Aldose Reductase, recombinant

Wako
Storage condition: Keep at -20 degrees C.

规格:0.4UNITS


Summary

This product is for research use only. Do not administer it to human.

Origin: Human muscle cell
Specific activity: 1.4 - 1.6 units/mg
Concentration: 1 units/mL
MW: approx. 36,000
Preparation: The enzyme is dissolved in 5 mM DTT, 50% glycerin and 50 mM Sodium phosphate buffer solution (pH 7.0).
Aldose Reductase is purified from the culture medium containing baculovirus-insect cell line 32d gene expression system. cDNA containing the entire protein coding region is expressed, and the enzyme exhibits the same properties and characteristics of human muscle and retina.
Aldose Reductase catalyzes the reduction of glucose to sorbitol.


Sorbitol is subsequently converted to fructose by sorbitol dehydrogenase.
These two enzymes are key components of the polyol pathway, the alternate route of glucose metabolism.  It is suggested that aldose reductase is involved in the pathogenesis of diabetic complications and the inhibitors continue to be developed at a vigorous pace.



[Reference]

Nishimura, C.  et al.: Biochim Biophys. Acta., 1078,
171 (1991).

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